High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway.

ABSTRACT: Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relationship between DM and TSCC was assessed in a retrospective study. The role and its mechanism of high glucose on the proliferation, metastatic potential of TSCC were investigated in vitro and in vivo. The prevalence rate of DM in patients with TSCC was 12.84%, which was significantly higher than that (9.7%) in the general population in China. Although no significant difference was observed in the overall survival (OS) rate, TSCC patients with DM have a 1.38-fold increase in relativ

SUBMITTER: Wang W 

PROVIDER: S-EPMC5762358 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature