Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice.

ABSTRACT: Invariant natural killer T (iNKT) cells develop into three subsets (NKT1, NKT2, and NKT17) expressing a distinct transcription factor profile, which regulates cytokine secretion upon activation. iNKT cell development in the thymus is modulated by signaling lymphocytic activation molecule family (SLAMF) receptors. In contrast to other SLAMF members, Ly9 (SLAMF3) is a non-redundant negative regulator of iNKT cell development. Here, we show that Ly9 influences iNKT cell lineage differentiation. Ly9-deficient mice on a BALB/c background contained a significantly expanded population of thymic NKT2 cells, while NKT1 cells were nearly absent in BALB/c.Ly9^-/- thymus. Conversely, the number of peripheral NKT1 cells in BALB/c.Ly9^-/- mice was comparable to that in wild-type mice

SUBMITTER: Cuenca M 

PROVIDER: S-EPMC5762399 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature