Characterising <i>cis</i>-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.

ABSTRACT:

Objective

To elucidate the genetic architecture of gene expression in pancreatic tissues.

Design

We performed expression quantitative trait locus (eQTL) analysis in histologically normal pancreatic tissue samples (n=95) using RNA sequencing and the corresponding 1000 genomes imputed germline genotypes. Data from pancreatic tumour-derived tissue samples (n=115) from The Cancer Genome Atlas were included for comparison.

Results

We identified 38 615 cis-eQTLs (in 484 genes) in histologically normal tissues and 39 713 cis-eQTL (in 237 genes) in tumour-derived tissues (false discovery rate <0.1), with the strongest effects seen near transcriptional start sites. Approximately 23% and 42% of genes with significant cis-eQTLs appeared to be specific for tu

SUBMITTER: Zhang M 

PROVIDER: S-EPMC5762429 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature