Combined surgery and radiation improves survival of tonsil squamous cell cancers.

ABSTRACT:

Objective

The study evaluated the addition of surgery (S) to radiation (RT) on survival of squamous cell carcinomas (SCC) of tonsillar-fossa (TF) in a modern cohort with similar epidemiology and treatment as current patients.

Study design

Retrospective analysis utilizing Surveillance, Epidemiology, and End Results (SEER) Program data.

Results

For all stages combined TF patients who received S+RT had superior OS (p < 0.01) and DSS (p < 0.01). For each stage OS and DSS was superior for S+RT (p < 0.05). In multivariate analysis, HRs for OS were statistically significantly higher for TF patients (stage 2, 3, and 4) receiving RT alone (p < 0.001).

Materials and methods

TF SCC patients treated with either S+RT or RT alone between 2004 and

SUBMITTER: Singh AK 

PROVIDER: S-EPMC5762522 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature