The efficacy and safety of tivantinib in the treatment of solid tumors: a systematic review and meta-analysis.

ABSTRACT:

Background

Tivantinib was designed to kill cancers by targeting the mesenchymal-epithelial transition (MET) protein. Although numerous tivantinib clinical trials are ongoing, tivantinib's efficacy and safety are still not clear. This meta-analysis was done to evaluate tivantinib's efficacy and safety in solid tumor treatment.

Materials and methods

PUBMED, EMBASE, and other databases were searched for eligible tivantinib clinical trials. The hazard ratio (HR) and 95% confidence interval (CI) of progression-free and overall survival (PFS and OS, respectively) were pooled and analyzed to evaluate tivantinib's efficacy. Data concerning adverse events (Grade ≥ 3) were pooled to calculate relative risks (RRs) with 95% CI for tivantinib-treated compared with control arms.

Findin

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5762579 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature