Fis is a global regulator critical for modulation of virulence factor production and pathogenicity of Dickeya zeae.

ABSTRACT: Dickeya zeae is the causal agent of rice foot rot disease, which has recently become a great threat to rice planting countries and regions. The pathogen produces a family of phytotoxins named zeamines that is critical for bacterial virulence, but little is known about the signaling pathways and regulatory mechanisms that govern zeamine production. In this study, we showed that a conserved transcriptional regulator Fis is involved in the regulation of zeamine production in D. zeae strain EC1. Deletion mutants were markedly attenuated in the virulence against rice seed germination. Transcriptome and phenotype analyses showed that Fis is a potent global transcriptional regulator modulating various virulence traits, including production of extracellular enzymes and exopolysaccharides, swimming

SUBMITTER: Lv M 

PROVIDER: S-EPMC5762655 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature