On-Chip Fluorescence Switching System for Constructing a Rewritable Random Access Data Storage Device.

ABSTRACT: We report the development of on-chip fluorescence switching system based on DNA strand displacement and DNA hybridization for the construction of a rewritable and randomly accessible data storage device. In this study, the feasibility and potential effectiveness of our proposed system was evaluated with a series of wet experiments involving 40 bits (5 bytes) of data encoding a 5-charactered text (KRIBB). Also, a flexible data rewriting function was achieved by converting fluorescence signals between "ON" and "OFF" through DNA strand displacement and hybridization events. In addition, the proposed system was successfully validated on a microfluidic chip which could further facilitate the encoding and decoding process of data. To the best of our knowledge, this is the first report on the use

SUBMITTER: Nguyen HH 

PROVIDER: S-EPMC5762669 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature