Thrombin@Fe₃O₄ nanoparticles for use as a hemostatic agent in internal bleeding.

ABSTRACT: Bleeding remains one of the main causes of premature mortality at present, with internal bleeding being the most dangerous case. In this paper, magnetic hemostatic nanoparticles are shown for the first time to assist in minimally invasive treatment of internal bleeding, implying the introduction directly into the circulatory system followed by localization in the bleeding zone due to the application of an external magnetic field. Nanoparticles were produced by entrapping human thrombin (THR) into a sol-gel derived magnetite matrix followed by grinding to sizes below 200 nm and subsequent colloidization. Prepared colloids show protrombotic activity and cause plasma coagulation in in vitro experiments. We also show here using a model blood vessel that the THR@ferria composite does not cause

SUBMITTER: Shabanova EM 

PROVIDER: S-EPMC5762673 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature