Prognostic values of DNA mismatch repair genes in ovarian cancer patients treated with platinum-based chemotherapy.

ABSTRACT:

Purpose

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR has been reported as a prognostic marker in certain cancers; however, the results are controversial. Therefore, identification of the prognostic value of MMR genes in ovarian cancer based on a large sample size is pivotal.

Methods

In the current study, we systemically investigated the prognostic roles of seven MMR genes, MSH2, MSH3, MSH6, MLH1, MLH3, PMS1 and PMS2, in ovarian cancer patients treated with platinum-based chemotherapy through "The Kaplan-Meier plotter" (KM plotter) database, which contains gene expression data and survival information of ovarian cancer patients.

Results

Among seven MMR genes, high mRNA levels of MSH6, MLH

SUBMITTER: Zhao C 

PROVIDER: S-EPMC5762798 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature