Location-Specific Oral Microbiome Possesses Features Associated With CKD.

ABSTRACT:

Introduction

Chronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pathogenesis.

Methods

In this study, we surveyed the oral microbiota in saliva, the left and right molars, and the anterior mandibular lingual area from 77 participants (18 with and 59 without CKD), and tested their association with CKD to identify microbial features that may be predictive of CKD status.

Results

The overall oral microbiota composition significantly differed by oral locations and was associated with CKD status in saliva and anterior mandibular lin

SUBMITTER: Hu J 

PROVIDER: S-EPMC5762954 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature