Association of a Low-Protein Diet With Slower Progression of CKD.

ABSTRACT:

Introduction

Reducing protein intake is recommended for slowing chronic kidney disease (CKD) progression, but assessment of its true effectiveness is sparse.

Methods

Using the Maroni formula, we assessed dietary protein intake (DPI) from 24-hour urinary urea excretion in 1594 patients (67% men and 33% women) with CKD, 784 of whom also had 7-day food records. Cause-specific hazard ratios (HRs) and 95% confidence intervals for the competing risks of DPI-associated end-stage renal disease (ESRD) or death were estimated in 1412 patients with baseline glomerular filtration rate ≥15 ml/min per 1.73 m², measured by ⁵¹Cr-EDTA renal clearance (mGFR).

Results

Overall, mean DPI estimated from urea excretion was 1.09 ± 0.30 g/kg of body weight per day (range

SUBMITTER: Metzger M 

PROVIDER: S-EPMC5762958 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature