APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death.

ABSTRACT:

Introduction

The relationship of APOL1 renal risk variants to cardiovascular disease (CVD) is controversial and was the subject of this investigation.

Methods

Age, cause of death, and nephrosclerosis (the latter defined by glomerulosclerosis) were analyzed in the autopsies of 162 African Americans and 136 whites genotyped for APOL1 risk alleles.

Results

Sudden deaths represented >75% of CVD autopsies for both races and all-risk genotypes. The average ages of CVD deaths for African Americans with 1 and 2 APOL1 risk alleles were, respectively, 7.0 years (P = 0.02) and 12.2 years (P < 0.01) younger than African Americans with 0 risk alleles and 8.7 years (P = 0.01) and 13.9 years (P = 0.01) younger than whites. Age differe

SUBMITTER: Hughson MD 

PROVIDER: S-EPMC5762961 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature