Temporal Association Between PLA2R Antibodies and Clinical Outcomes in Primary Membranous Nephropathy.

ABSTRACT:

Introduction

Autoantibodies to M-type phospholipase A2 receptor (aPLA2R) are seen in two-thirds of patients with primary membranous nephropathy (PMN) and are associated with disease activity. However, the precise temporal dynamics between the presence and amount of aPLA2R in circulation, as well as the clinical activity, are not known. We evaluated the temporal association between disease activity and serum aPLA2R during and after treatment in PMN.

Methods

The study included all patients with PMN and elevated aPLA2R who were started on immunosuppressive therapy for persistent nephrotic syndrome at a single center between December 2014 and December 2015. Serum samples were tested for aPLA2R at baseline and at monthly intervals for 6 months. Clinical details were collected mon

SUBMITTER: Ramachandran R 

PROVIDER: S-EPMC5762964 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature