Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion.

ABSTRACT: Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca²⁺ imaging in hippocampal area CA1 of wild-type and Df(16)A^+/- mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice was supported by stable spatial maps and robust remapping of place fields toward the goal location. Df(16)A^+/- mice showed a significant learning deficit accompa

SUBMITTER: Zaremba JD 

PROVIDER: S-EPMC5763006 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature