Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D₃ towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum.

ABSTRACT:

Background

Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D₃ is expected to work synergistically.

Objective

To determine the effect of Curcuma xanthorrhiza supplementation on vitamin D₃ administration to SLEDAI, IL-6, and TGF-β1 serum in SLE patients with hypovitamin D.

Methods

This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and Curcuma xanthorrhi

SUBMITTER: Singgih Wahono C 

PROVIDER: S-EPMC5763117 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature