Expression of Membrane-Bound CC Chemokine Ligand 20 on Follicular T Helper Cells in T-B-Cell Conjugates.

ABSTRACT: The CC chemokine receptor 6 (CCR6) and its sole chemokine ligand CC chemokine ligand 20 (CCL20) display an emerging role in the coordination of humoral immune responses. Recent studies demonstrate a role of this chemokine axis in the migration of B cells to key immunological sites during an immune response, and facilitating the generation of high-quality antibodies. Very little, however, is known about CCL20 and its role in these functions. We undertook a preliminary investigation into the expression and function of CCL20 and demonstrate its well-noted upregulation in the spleen during immunization. Furthermore, we show that most follicular T helper (Tfh) cells can be CCR6⁺ and can produce CCL20. Surprisingly, CCL20 cannot only be found in the cytoplasm but also on the surface o

SUBMITTER: Lee AYS 

PROVIDER: S-EPMC5763129 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature