Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

To explore the relationship between insulin levels and nonpsychotic dementia.

Methods

Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860).

Results

50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges' g = 1.196, 95% CI = 0.238 to 2

SUBMITTER: Pan QX 

PROVIDER: S-EPMC5763205 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature