Differential responses of innate immunity triggered by different subtypes of influenza a viruses in human and avian hosts.

ABSTRACT:

Background

Innate immunity provides first line of defense against viral infections. The interactions between hosts and influenza A virus and the response of host innate immunity to viral infection are critical determinants for the pathogenicity or virulence of influenza A viruses. This study was designed to investigate global changes of gene expression and detailed responses of innate immune systems in human and avian hosts during the course of infection with various subtypes of influenza A viruses, using collected and self-generated transcriptome sequencing data from human bronchial epithelial (HBE), human tracheobronchial epithelial (HTBE), and A549 cells infected with influenza A virus subtypes, namely H1N1, H3N2, H5N1 HALo mutant, and H7N9, and from ileum and lung of chicken an

SUBMITTER: Cao Y 

PROVIDER: S-EPMC5763291 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature