Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions.

ABSTRACT:

Background

Protein post-translational modification (PTM) plays an essential role in various cellular processes that modulates the physical and chemical properties, folding, conformation, stability and activity of proteins, thereby modifying the functions of proteins. The improved throughput of mass spectrometry (MS) or MS/MS technology has not only brought about a surge in proteome-scale studies, but also contributed to a fruitful list of identified PTMs. However, with the increase in the number of identified PTMs, perhaps the more crucial question is what kind of biological mechanisms these PTMs are involved in. This is particularly important in light of the fact that most protein-based pharmaceuticals deliver their therapeutic effects through some form of PTM. Yet, our understand

SUBMITTER: Su MG 

PROVIDER: S-EPMC5763307 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature