Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.

ABSTRACT:

Objectives

Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val¹⁵⁸ Met genotype and DRD2 C⁹⁵⁷ T genotype) affect the development of cognitive deficits in PD.

Materials and methods

One hundred and 34 patients with idiopathic PD, participating in a regional, population-based study of incident parkinsonism, underwent genotyping. After extensive baseline investigations (including imaging and biomarker analyses), the patients were

SUBMITTER: Backstrom D 

PROVIDER: S-EPMC5763317 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature