Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease.

ABSTRACT: The human gut is colonized by a large number of microorganisms (∼10¹³ bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencie

SUBMITTER: Mangalam A 

PROVIDER: S-EPMC5763484 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature