MDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs.

ABSTRACT: BACKGROUND:Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is related to a number of metabolic or aging diseases including diabetes, chronic lung disease, Parkinson's disease, and Alzheimer's disease. Due to the lack of computational methods dedicated to exploring motif signatures of protein carbonylation sites, we were motivated to exploit an iterative statistical method to characterize and identify carbonylated sites with motif signatures. RESULTS:By manually curating experimental data from research articles, we obtained 332, 144, 135, and 140 verified substrate sites for K (lysine), R (arginine), T (threonine), and P (proline) resid

SUBMITTER: Kao HJ 

PROVIDER: S-EPMC5763492 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature