Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis.

ABSTRACT:

Background

The post-thrombotic syndrome frequently develops in patients with proximal deep-vein thrombosis despite treatment with anticoagulant therapy. Pharmacomechanical catheter-directed thrombolysis (hereafter "pharmacomechanical thrombolysis") rapidly removes thrombus and is hypothesized to reduce the risk of the post-thrombotic syndrome.

Methods

We randomly assigned 692 patients with acute proximal deep-vein thrombosis to receive either anticoagulation alone (control group) or anticoagulation plus pharmacomechanical thrombolysis (catheter-mediated or device-mediated intrathrombus delivery of recombinant tissue plasminogen activator and thrombus aspiration or maceration, with or without stenting). The primary outcome was development of the post-thrombotic syndrome betwe

SUBMITTER: Vedantham S 

PROVIDER: S-EPMC5763501 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature