Tensor decomposition-based unsupervised feature extraction identifies candidate genes that induce post-traumatic stress disorder-mediated heart diseases.

ABSTRACT:

Background

Although post-traumatic stress disorder (PTSD) is primarily a mental disorder, it can cause additional symptoms that do not seem to be directly related to the central nervous system, which PTSD is assumed to directly affect. PTSD-mediated heart diseases are some of such secondary disorders. In spite of the significant correlations between PTSD and heart diseases, spatial separation between the heart and brain (where PTSD is primarily active) prevents researchers from elucidating the mechanisms that bridge the two disorders. Our purpose was to identify genes linking PTSD and heart diseases.

Methods

In this study, gene expression profiles of various murine tissues observed under various types of stress or without stress were analyzed in an integrated manner using te

SUBMITTER: Taguchi YH 

PROVIDER: S-EPMC5763504 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature