Continuous measurement of breast tumour hormone receptor expression: a comparison of two computational pathology platforms.

ABSTRACT:

Aims

Computational pathology platforms incorporate digital microscopy with sophisticated image analysis to permit rapid, continuous measurement of protein expression. We compared two computational pathology platforms on their measurement of breast tumour oestrogen receptor (ER) and progesterone receptor (PR) expression.

Methods

Breast tumour microarrays from the Nurses' Health Study were stained for ER (n=592) and PR (n=187). One expert pathologist scored cases as positive if ≥1% of tumour nuclei exhibited stain. ER and PR were then measured with the Definiens Tissue Studio (automated) and Aperio Digital Pathology (user-supervised) platforms. Platform-specific measurements were compared using boxplots, scatter plots and correlation statistics. Classification of ER and PR pos

SUBMITTER: Ahern TP 

PROVIDER: S-EPMC5763511 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature