Aberrant DNA methylation associated with Alzheimer's disease in the superior temporal gyrus.

ABSTRACT: Abnormal DNA methylation patterns have been demonstrated to be associated with the pathogenesis of Alzheimer's disease (AD). The present study aimed to identify differential methylation in the superior temporal gyrus (STG) of patients with late-onset AD based on epigenome-wide DNA methylation data by bioinformatics analysis. The genome-wide DNA methylation data in the STG region of 34 patients with late-onset AD and 34 controls without dementia were recruited from the Gene Expression Omnibus database. Through systemic quality control, differentially methylated CpG sites were determined by the Student's t-test and mean methylation value differences between the two conditions. Hierarchical clustering analysis was applied to assess the classification performance of differentially methylated C

SUBMITTER: Gao Z 

PROVIDER: S-EPMC5763665 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature