Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis.

ABSTRACT:

Background

Microbiota integrity is essential for a growing number of physiological processes. Consequently, disruption of microbiota homeostasis correlates with a variety of pathological states. Importantly, commensal microbiota provide a shield against invading bacterial pathogens, probably by direct competition. The impact of viral infections on host microbiota composition and dynamics is poorly understood. Influenza A viruses (IAV) are common respiratory pathogens causing acute infections. Here, we show dynamic changes in respiratory and intestinal microbiota over the course of a sublethal IAV infection in a mouse model.

Results

Using a combination of 16S rRNA gene-specific next generation sequencing and qPCR as well as culturing of bacterial organ content, we found body

SUBMITTER: Yildiz S 

PROVIDER: S-EPMC5763955 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature