The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs.

ABSTRACT:

Background

Recently, supplementation of L-carnitine to obese rats was found to improve the carnitine status and to counteract an obesity-induced muscle fiber transition from type I to type II. However, it has not been resolved if the change of muscle fiber distribution induced in obese rats and the restoration of the "normal" muscle fiber distribution, which is found in lean rats, in obese rats by supplemental L-carnitine is causally linked with the carnitine status. In the present study we hypothesized that fiber type distribution in skeletal muscle is dependent on carnitine status.

Methods

To test this, an experiment with 48 piglets which were randomly allocated to four groups (n = 12) was performed. All piglets were given orally either 60 mg sodium bicarbonate/kg b

SUBMITTER: Kaup D 

PROVIDER: S-EPMC5764002 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature