Correlation between polymorphisms in toll-like receptor genes and the activity of hepatitis B virus among treatment-naive patients: a case-control study in a Han Chinese population.

ABSTRACT:

Background

Because of the high prevalence and absence of cure for infection, chronic hepatitis B virus (HBV) infection has been acknowledged as a pressing public health issue. Toll-like receptors (TLRs) activate the human innate immune system and the polymorphisms in TLRs may alter their function. The present study aimed to investigate the association between TLR polymorphisms and disease progression of chronic HBV infection.

Methods

During the study period, 211 treatment-naïve patients with chronic HBV infection were recruited, and blood samples were collected from each individual. Matrix-assisted laser desorption/ionization time of flight mass spectrometry was employed to genotype the selected TLR polymorphisms after human genome extraction. In addition, HbsAg, TNF-α, and

SUBMITTER: Lin Y 

PROVIDER: S-EPMC5764005 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature