Developmental and adult-specific processes contribute to de novo neuromuscular regeneration in the lizard tail.

ABSTRACT: Peripheral nerves exhibit robust regenerative capabilities in response to selective injury among amniotes, but the regeneration of entire muscle groups following volumetric muscle loss is limited in birds and mammals. In contrast, lizards possess the remarkable ability to regenerate extensive de novo muscle after tail loss. However, the mechanisms underlying reformation of the entire neuromuscular system in the regenerating lizard tail are not completely understood. We have tested whether the regeneration of the peripheral nerve and neuromuscular junctions (NMJs) recapitulate processes observed during normal neuromuscular development in the green anole, Anolis carolinensis. Our data confirm robust axonal outgrowth during early stages of tail regeneration and subsequent NMJ formation within

SUBMITTER: Tokuyama MA 

PROVIDER: S-EPMC5764105 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature