X-inactive-specific transcript of peripheral blood cells is regulated by exosomal Jpx and acts as a biomarker for female patients with hepatocellular carcinoma.

ABSTRACT:

Background

Long noncoding ribonucleic acid (lncRNA) X-inactive-specific transcript (Xist) was reported to affect cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, there are rare reports focusing on the diagnostic evaluation and regulatory mechanism of Xist expression from peripheral blood cells of patients with HCC.

Methods

In this study, a cohort of 206 female participants including healthy volunteers (HVs) and patients with chronic hepatitis B (CHB), cirrhosis and HCC was recruited. Coculture system was used to evaluate the effects of exosomal JPX transcript, XIST activator (Jpx) on Xist expression of blood cells.

Results

First, Xist expressions of both peripheral blood mononuclear cells and granulocytes were upregulated in female patient

SUBMITTER: Ma X 

PROVIDER: S-EPMC5764152 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature