Saccades in progressive supranuclear palsy - maladapted, irregular, curved, and slow.

ABSTRACT:

Background and objectives

Slowed and curved rapid eye movements, saccades, are the well-known features of progressive supranuclear palsy (PSP). We hypothesized that the saccades in PSP are not only slow and curved, but they are also irregular and have timing deficits.

Methods

We tested this hypothesis in 12 patients with PSP by measuring vertical and horizontal visually guided saccades using a limbus tracker.

Results

Both, horizontal and vertical saccades were slow and had irregular trajectory and velocity profiles, but deficits were much more robust in vertical saccades. The irregularity in the saccade velocity was due to premature interruptions that either completely stopped the eyes, or moved the eyes at much slower velocity along or in the opposite direction of th

SUBMITTER: Shaikh AG 

PROVIDER: S-EPMC5764187 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature