An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.

ABSTRACT: [¹⁸F]Fluorodeoxyglucose-PET/CT (¹⁸F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as ¹⁸F-FDG through PET/CT or [^123/125I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate t

SUBMITTER: Zhang F 

PROVIDER: S-EPMC5764189 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature