HIV-Specific CD8⁺ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

ABSTRACT: Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8⁺ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory, follicular CXCR5⁺, and HIV-specific CD8⁺ T cells from LNs do not manifest the properties of cytolytic CD8⁺ T cells. While the frequency of follicular CXCR5⁺ CD8⁺ T cells was strongly inversely associated with peripheral viremia, this association was not dependent on cytolytic CXCR5⁺ CD8⁺ T cells. Moreover, the poor cytolytic activity of LN CD8⁺ T cells was linked to a compartmentalized dissociation between effector programming and the transcription factor

SUBMITTER: Reuter MA 

PROVIDER: S-EPMC5764192 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature