Metabolomic markers of fatigue: Association between circulating metabolome and fatigue in women with chronic widespread pain.

ABSTRACT:

Background

Fatigue is a sensation of unbearable tiredness that frequently accompanies chronic widespread musculoskeletal pain (CWP) and inflammatory joint disease. Its mechanisms are poorly understood and there is a lack of effective biomarkers for diagnosis and onset prediction. We studied the circulating metabolome in a population sample characterised for CWP to identify biomarkers showing specificity for fatigue.

Material and methods

Untargeted metabolomic profiling was conducted on fasting plasma and serum samples of 1106 females with and without CWP from the TwinsUK cohort. Linear mixed-effects models accounting for covariates were used to determine relationships between fatigue and metabolites. Receiver operating curve (ROC)-analysis was used to determine predictive va

SUBMITTER: Freidin MB 

PROVIDER: S-EPMC5764223 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature