Sex-dependent impact of early-life stress and adult immobilization in the attribution of incentive salience in rats.

ABSTRACT: Early life stress (ELS) induces long-term effects in later functioning and interacts with further exposure to other stressors in adulthood to shape our responsiveness to reward-related cues. The attribution of incentive salience to food-related cues may be modulated by previous and current exposures to stressors in a sex-dependent manner. We hypothesized from human data that exposure to a traumatic (severe) adult stressor will decrease the attribution of incentive salience to reward-associated cues, especially in females, because these effects are modulated by previous ELS. To study these factors in Long-Evans rats, we used as an ELS model of restriction of nesting material and concurrently evaluated maternal care. In adulthood, the offspring of both sexes were exposed to acute immobilizat

SUBMITTER: Fuentes S 

PROVIDER: S-EPMC5764258 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature