Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia.

ABSTRACT:

Background

Cerebral extraction of diffusively distributed substances like oxygen has been suggested to change according to the cerebral blood flow (CBF) and status of the microvasculature. The relationships between the cerebral extraction of diffusively distributed lipophilic tracers and the severity of cerebral ischemia has not yet been clarified. In the present study, we attempted to elucidate the association between the extraction fraction of the lipophilic tracer I-123 iomazenil (IMZ) (IMZ-EF) and the oxygen extraction fraction (OEF) derived from O-15 PET in patients with chronic steno-occlusive disease of internal carotid artery (ICA) or middle cerebral artery (MCA).

Methods

Seven patients with unilateral chronic severe stenosis or occlusion of the middle cerebral/inter

SUBMITTER: Kato H 

PROVIDER: S-EPMC5764280 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature