Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis.

ABSTRACT:

Background

The rate of alcohol relapse among patients who underwent liver transplantation for alcoholic hepatitis (AH) is not precisely known.

Aim

Synthesize the available evidence on liver transplantation for AH to assess alcohol relapse and 6-month survival.

Methods

Meta-analysis of trials evaluating liver transplantation for AH, either clinically severe or diagnosed on the explant.

Results

Eleven studies were included. The pooled estimate rate for alcohol relapse was 0.22 (95% CI = 0.12-0.36) in overall analysis with high heterogeneity between studies (I2 = 76%), 0.20 (95% CI = 0.07-0.43) in the subgroup analysis including patients with clinically severe AH (I2 = 84%), 0.14 (95% CI = 0.08-0.23) among patients with clinically severe AH in sensitivity analysis

SUBMITTER: Marot A 

PROVIDER: S-EPMC5764315 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature