Clock mediates liver senescence by controlling ER stress.

ABSTRACT: Accumulated evidence indicates that circadian genes regulate cell damage and senescence in most mammals. Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) regulate longevity in many organisms. However, the specific mechanisms of the relationship between the circadian clock and the two stress processes in organisms are poorly understood. Here, we show that Clock-mediated Pdia3 expression is required to sustain reactive oxidative reagents and ER stress. First, ER stress and ROS are strongly activated in the liver tissue of Clock^∆19 mutant mice, which exhibit a significant aging phenotype. Next, transcription of Pdia3 is mediated by the circadian gene Clock, but this process is affected by the Clock^∆19 mutant due to the low affinity of the

SUBMITTER: Yuan G 

PROVIDER: S-EPMC5764397 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature