Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression.

ABSTRACT: Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection of the signals which influence tumor progression is needed. Cancer stroma plays a critical role in tumor proliferation, invasion and chemoresistance. Here, we sought to identify and characterize exosomal microRNAs as mediators of stromal-tumor signaling. In vitro, we demonstrated that fibroblast exosomes are transferred to colorectal cancer cells, with a resultant increase in cellular microRNA levels, impacting proliferation and chemoresistance. To probe this further, exosomal microRNAs were profiled from paired patient-derived normal and cancer-associated fibroblasts, from an ongoing prospective biomarker study. An exosomal ca

SUBMITTER: Bhome R 

PROVIDER: S-EPMC5764398 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature