Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records.

ABSTRACT:

Introduction

To evaluate unmet clinical need in unselected hypertrophic cardiomyopathy (HCM) patients to determine the risk of a wide range of subsequent cardiovascular disease endpoints and safety endpoints relevant for trial design.

Methods

Population based cohort (CALIBER, linked primary care, hospital and mortality records in England, period 1997-2010), all people diagnosed with HCM were identified and matched by age, sex and general practice with ten randomly selected people without HCM. Random-effects Poisson models were used to assess the associations between HCM and cardiovascular diseases and bleeding.

Results

Among 3,290,455 eligible people a diagnosis of hypertrophic cardiomyopathy was found in 4 per 10,000. Forty-one percent of the 1,160 individuals with h

SUBMITTER: Pujades-Rodriguez M 

PROVIDER: S-EPMC5764451 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature