An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.

ABSTRACT: A robust method based on reverse engineering was utilized to construct the ion-channel conductance functions for airway epithelial sodium channels (ENaC), the cystic fibrosis transmembrane conductance regulator (CFTR), and calcium-activated chloride channels (CaCC). The ion-channel conductance models for both normal (NL) and cystic fibrosis (CF) airway epithelia were developed and then coupled to an adenosine triphosphate (ATP) metabolism model and a fluid transport model (collectively called the integrated cell model) to investigate airway surface liquid (ASL) volume regulation and hence mucus concentration, by mechanical forces in NL and CF human airways. The epithelial cell models for NL and CF required differences in Cl^- secretion (decreased in CF) and Na⁺ absorpt

SUBMITTER: Wu D 

PROVIDER: S-EPMC5764545 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature