Different shades of default mode disturbance in schizophrenia: Subnodal covariance estimation in structure and function.

ABSTRACT: Schizophrenia is a devastating mental disease with an apparent disruption in the highly associative default mode network (DMN). Interplay between this canonical network and others probably contributes to goal-directed behavior so its disturbance is a candidate neural fingerprint underlying schizophrenia psychopathology. Previous research has reported both hyperconnectivity and hypoconnectivity within the DMN, and both increased and decreased DMN coupling with the multimodal saliency network (SN) and dorsal attention network (DAN). This study systematically revisited network disruption in patients with schizophrenia using data-derived network atlases and multivariate pattern-learning algorithms in a multisite dataset (n = 325). Resting-state fluctuations in unconstrained brain states were u

SUBMITTER: Lefort-Besnard J 

PROVIDER: S-EPMC5764781 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature