Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.

ABSTRACT: Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD). ¹⁸ F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between ¹⁸ F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4). Amnestic AD patients had deficits in memory; lvPPA in language; and both amne

SUBMITTER: Phillips JS 

PROVIDER: S-EPMC5764792 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature