The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids.

ABSTRACT: The histologic spectrum of nonalcoholic fatty liver disease (NAFLD) includes fatty liver (NAFL) and steatohepatitis (NASH), which can progress to cirrhosis in up to 20% of NASH patients. Bile acids (BA) are linked to the pathogenesis and therapy of NASH. We (1) characterized the plasma BA profile in biopsy-proven NAFL and NASH and compared to controls and (2) related the plasma BA profile to liver histologic features, disease activity, and fibrosis. Liquid chromatography/mass spectrometry quantified BAs. Descriptive statistics, paired and multiple group comparisons, and regression analyses were performed. Of 86 patients (24 controls, 25 NAFL, and 37 NASH; mean age 51.8 years and body mass index 31.9 kg/m² ), 66% were women. Increased total primary BAs and decreased secondary BAs

SUBMITTER: Puri P 

PROVIDER: S-EPMC5764808 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature