Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis.

ABSTRACT: Although autoimmune hepatitis (AIH) can be treated with corticosteroid-based first-line therapy, incomplete remission is associated with progressive liver fibrosis. So far accepted predictors of the subsequent treatment response of AIH patients are lacking. Therefore, we analysed baseline parameters, including iron homeostasis and cytokine levels, in 60 children with paediatric AIH (pAIH). In contrast to adults, elevated serum markers indicating iron overload were not commonly found in children. Therefore, ferritin was not predictive of the treatment response in pAIH. Although baseline immunoglobulins were lower in pAIH children with subsequent complete biochemical remission (BR) upon standard first-line therapy, only lower AIH scores (≤16 points) could predict BR upon standard therapy in

SUBMITTER: Diestelhorst J 

PROVIDER: S-EPMC5764983 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature