Sequential forward and reverse transport of the Na⁺ Ca²⁺ exchanger generates Ca²⁺ oscillations within mitochondria.

ABSTRACT: Mitochondrial Ca²⁺ homoeostasis regulates aerobic metabolism and cell survival. Ca²⁺ flux into mitochondria is mediated by the mitochondrial calcium uniporter (MCU) channel whereas Ca²⁺ export is often through an electrogenic Na⁺-Ca²⁺ exchanger. Here, we report remarkable functional versatility in mitochondrial Na⁺-Ca²⁺ exchange under conditions where mitochondria are depolarised. Following physiological stimulation of cell-surface receptors, mitochondrial Na⁺-Ca²⁺ exchange initially operates in reverse mode, transporting cytosolic Ca²⁺ into the matrix. As matrix Ca²⁺ rises, the exchanger reverts to its forward mode state, extruding Ca²⁺. Transitions between r

SUBMITTER: Samanta K 

PROVIDER: S-EPMC5765001 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature