Microbial synthesis of a useful optically active (+)-isomer of lactone with bicyclo[4.3.0]nonane structure.

ABSTRACT: Lactone 2a of a bicyclo[4.3.0]nonane structure is a good starting material for synthesis of many attractive compounds. Enantiomerically enriched (-)-(3aR,7aS)-lactone 2a is produced by whole cells of bacteria. In order to examine the impact of the absolute configuration on biological activity we evaluated the process affording the opposite isomer. To this purpose Candida pelliculosa ZP22 characterized by high dehydrogenase activity was used. The goal of presented work was to perform bioreactor scale microbial one-pot oxidation of diol with selected yeast strain C. pelliculosa ZP22 to obtain chiral (+)-(3aS,7aR)-lactone 2a. The idea was to influence on alcohol dehydrogenase activity by increasing the activity of pro-(+)-ADH and simultanously diminishing the activity of pro-(-)-ADH. The opti

SUBMITTER: Boratynski F 

PROVIDER: S-EPMC5765023 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature