Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.

ABSTRACT:

Purpose

Paracetamol is one of the world's most commonly used drugs. In overdose, it is well established to be hepatotoxic. The aim of this review was to identify factors that have been, or actually are, associated with the development of liver injury after paracetamol exposure in humans.

Method

Google Scholar and PubMed were searched on various dates between December 2016 and March 2017. Papers identified had their references analysed for further studies that might be relevant.

Results

At the time of writing, there was little good quality clinical evidence-from studies of paracetamol overdose or therapeutic use-to suggest that any groups of people are relatively protected from, or are at greater risk of, liver injury. The factors that were historically used to indicat

SUBMITTER: Caparrotta TM 

PROVIDER: S-EPMC5765191 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature