Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population-based cohort study.

ABSTRACT:

Purpose

To describe patients initiating dimethyl fumarate (DMF) and measure persistence with DMF, discontinuation, and switching in treatment-naïve DMF patients and patients switching to DMF from other multiple sclerosis disease-modifying treatments (DMTs).

Methods

A population-based cohort study of all Stockholm County residents initiating DMF from 9 May 2014 until 31 May 2017. All data were derived from a regional database that collects individual-level data on healthcare and drug utilization of all residents. The study outcomes were persistence with DMF and DMF discontinuation and switching to other DMTs. Persistence was measured as the number of days until either DMF discontinuation (treatment gap ≥ 60 days) or switching to another DMT.

Results

The study included

SUBMITTER: Eriksson I 

PROVIDER: S-EPMC5765201 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature